The Black Stars start the last set of group games with four points, one ahead of Mali and two ahead of the DR Congo.
It means a draw will be enough to take them into the last eight while a win ensures they top the standings.
Mubarak Wakaso, who is suspended and injured, misses out while Richmond Boakye and Anthony Annan are doubtful.
A win over Niger, who gained their first-ever Nations Cup point in their last match on Thursday, will ensure they avoid a quarter-final meeting with hosts South Africa and instead take on the Cape Verde on Saturday.
But Niger, who are participating at only their second finals, are also still in with a chance if they continue the run of upsets at the tournament and beat the Black Stars at Port Elizabeth’s Nelson Mandela Bay Stadium.
Meanwhile, atmosphere in the Nelson Mandela Bay Stadium is said to be Charged.
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