Duminy is currently undergoing rehab treatment for a left knee injury.
The target for his return was initially stated as the second Test starting in Port Elizabeth on December 26, but it appears that the 30-year-old could be sidelined for the entire three-Test series.
Duminy participated as celebrity a chef on a local TV programme on Monday when he revealed that a more likely return to action would be the T20 and ODI series.
The first Test against the Windies starts in Centurion on December 17, with the series concluding in Cape Town from January 2-6.
The three-game T20 series starts on January 9. It will be followed by a five-game ODI series starting on January 16.